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Elevated D-dimer on admission may predict poor prognosis in childhood influenza associated encephalopathy

Huizhen Wang1, Lingkong Zeng1, Xingfeng Cheng2

  • 1Department of Neonatal Intensive Care Unit, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, , Huazhong University of Science and Technology, Wuhan, 430016, China.

Scientific Reports
|January 24, 2025
PubMed

Insights

Influenza-associated encephalopathy (IAE) often leads to poor outcomes. Elevated D-dimer levels are identified as a significant independent risk factor for predicting poor prognosis in children with IAE.

Area of Science:

  • Pediatric Intensive Care
  • Neurology
  • Infectious Diseases

Background:

  • Influenza-associated encephalopathy (IAE) is a severe neurological complication of influenza infection in children.
  • Identifying risk factors for poor prognosis is crucial for timely intervention and improved patient outcomes.

Purpose of the Study:

  • To determine the independent risk factors associated with a poor prognosis in children diagnosed with IAE.
  • To evaluate the predictive value of D-dimer levels in assessing IAE prognosis.

Main Methods:

  • Retrospective analysis of 56 children with IAE treated in a pediatric intensive care unit from January 2022 to December 2023.
  • Univariate and binary logistic regression analyses were employed to identify risk factors for poor prognosis.

Main Results:

  • Nearly half (46.4%) of the children experienced a poor prognosis.
  • Elevated D-dimer levels were identified as an independent risk factor for poor prognosis (OR=1.440, P=0.023).
  • A D-dimer level ≥1.18 mg/L FEU predicted poor prognosis with 65.4% sensitivity and 96.7% specificity.

Conclusions:

  • IAE is associated with a high incidence of poor prognosis.
  • D-dimer is a valuable biomarker for predicting poor prognosis in pediatric IAE.
  • Further multicenter studies are warranted to validate these findings due to the study's limitations.

Keywords:
Acute encephalopathyAcute necrotizing encephalopathyChildrenInfluenzaInfluenza-associated encephalopathyPoor prognosisRisk factors

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