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Effects of perfluorolauric acid exposure on intestinal microbial community and physiological health indicators in
Jiaqiong Zhang1, Lingli Min2, Jiamin Chang1
1College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, 362000, China.
Abstract:
The present study aims to investigate the effects of Perfluorolauric Acid (PFLA) on the gut microbiota community and the physiological health of mice. The experiment was conducted by setting a control group (CTRL) and an experimental group (PFLA), exposing mice to PFLA and observing changes in their gut microbiota community and physiological health indicators. The results showed that exposure to PFLA significantly altered the β diversity of the gut microbiota in mice, as evidenced by NMDS, PCoA, and PCA analyses, indicating a clear change in microbial community structure between the PFLA group and the CTRL group. Moreover, PFLA led to a decrease in α diversity of the gut microbiota, with certain specific species such as CryptoBacteroides significantly increasing in the PFLA group while Odoribacter_laneus decreased. In terms of physiological health, exposure to PFLA resulted in increased liver inflammation, lipid abnormalities, and caused histological changes in the colon, such as ulcerative colitis and damage to glandular structures. These findings suggest that PFLA has adverse effects on the gut microbiota community and physiological health of mice. This study can provide foundational data and references for the pollution control of PFLA.
Insights
Perfluorolauric Acid (PFLA) exposure significantly alters mouse gut microbiota diversity and structure. PFLA also causes liver inflammation, lipid issues, and colon damage, indicating adverse health effects.
Area of Science:
- Environmental Science
- Microbiology
- Toxicology
Background:
- Perfluorolauric Acid (PFLA) is a persistent environmental contaminant.
- Understanding its impact on gut microbiota and host health is crucial.
Purpose of the Study:
- To investigate the effects of PFLA exposure on the gut microbiota community.
- To assess the impact of PFLA on the physiological health of mice.
Main Methods:
- Mice were divided into a control group (CTRL) and a Perfluorolauric Acid (PFLA) exposed group.
- Gut microbiota community structure was analyzed using NMDS, PCoA, and PCA.
- Physiological health indicators, including liver and colon histology, were examined.
Main Results:
- PFLA exposure significantly altered gut microbiota β diversity, indicating changes in community structure.
- α diversity of the gut microbiota decreased in the PFLA group.
- PFLA exposure led to increased liver inflammation, lipid abnormalities, and colon damage (ulcerative colitis, glandular structure damage).
Conclusions:
- Perfluorolauric Acid (PFLA) adversely affects the gut microbiota community and physiological health in mice.
- Findings provide data for PFLA pollution control strategies.
- Highlights the toxicological impact of PFLA on host-microbe interactions.
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