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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Updated: May 31, 2025

Isolation of Mouse Salivary Gland Stem Cells
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Salivary gland stem/progenitor cells: advancing from basic science to clinical applications.

Jimpi Langthasa1, Li Guan1, Shyam Lal Jinagal2

  • 1Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr Clinic D, Stanford, CA, MC 584794305, USA.

Cell Regeneration (London, England)
|January 24, 2025
PubMed
Summary
This summary is machine-generated.

Salivary gland stem/progenitor cells (SSPCs) show promise for regenerative medicine in treating salivary gland dysfunction. Research explores SSPC characteristics, therapies, and challenges for clinical application.

Keywords:
Clinical implicationsRegenerative medicineSalivary gland stem/progenitor cells (SSPCs)Salivary glands

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Tissue Engineering

Background:

  • Salivary gland dysfunction affects patients with Sjögren's syndrome, radiation therapy side effects, and aging.
  • Salivary gland stem/progenitor cells (SSPCs) are crucial for salivary gland structure and function.
  • Understanding SSPCs is vital for developing treatments for salivary hypofunction.

Purpose of the Study:

  • To provide a comprehensive review of salivary gland stem/progenitor cells (SSPCs).
  • To discuss the characteristics, isolation, culture, and differentiation of SSPCs.
  • To explore current and future cell- and tissue-based regenerative therapies for salivary gland dysfunction.

Main Methods:

  • Literature review of SSPC research.
  • Analysis of SSPC characteristics, isolation, and culture techniques.
  • Evaluation of differentiation pathways and regenerative applications.

Main Results:

  • SSPCs possess significant potential for salivary gland regeneration.
  • Cell- and tissue-based therapies, including transplantation and bioengineered organs, are advancing.
  • Challenges remain in translating SSPC research into clinical practice.

Conclusions:

  • SSPCs are a promising source for regenerative medicine in salivary gland disorders.
  • Further research is needed to overcome challenges and advance SSPC-based therapies.
  • Future directions include refining cell-based approaches and bioengineered solutions for salivary gland restoration.