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The prognostic value of systemic inflammation response index in digestive system carcinomas: a systematic review and meta-analysis

  • 0Department of Infections, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Bmc Gastroenterology +

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January 25, 2025

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January 25, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated systemic inflammation response index (SIRI) is linked to worse outcomes in digestive system carcinomas (DSC). This marker shows potential for predicting survival in DSC patients, aiding clinical decisions.

Area Of Science

  • Oncology
  • Inflammation Biomarkers
  • Cancer Prognostics

Background

  • Digestive system carcinomas (DSC) are a growing concern, contributing significantly to cancer mortality.
  • The systemic inflammation response index (SIRI) is emerging as a key indicator of prognosis in various DSC types.

Purpose Of The Study

  • To evaluate the prognostic significance of the systemic inflammation response index (SIRI) in patients diagnosed with digestive system carcinomas (DSC).

Main Methods

  • A meta-analysis was conducted, including 34 cohort studies with 9628 participants, analyzing pre-treatment SIRI levels.
  • Hazard ratios (HRs) and 95% confidence intervals (CIs) were synthesized using a random-effect model.
  • Overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), time to progression (TTP), and disease-specific survival (DSS) were assessed.

Main Results

  • Elevated SIRI was significantly associated with poorer OS (HR=1.98), PFS (HR=2.36), DFS (HR=1.80), TTP (HR=2.03), and DSS (HR=1.99).
  • Significant heterogeneity was noted for OS and PFS, but not for DFS, TTP, or DSS.
  • Post-treatment SIRI changes also correlated with survival outcomes, with increases linked to poorer prognosis and decreases to improved outcomes.

Conclusions

  • The systemic inflammation response index (SIRI) is a valuable prognostic biomarker for digestive system carcinomas (DSC).
  • Elevated SIRI levels indicate poorer clinical outcomes, offering a predictive tool for patient survival.

Keywords:

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