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Related Concept Videos

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: May 31, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
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Capecitabine enhances sensitivity to oxaliplatin in advanced gastric cancer and the effects on patients' FOXP1 and

Xinyu Guo1, Yi Liu2

  • 1Department of General Surgery, Fuwai Central China Cardiovascular Hospital, No. 1, Fuwai Road, Zhengdong New District, Zhengzhou, Henan, 451460, PR China. guoxinyugxy@21cn.com.

BMC Gastroenterology
|January 25, 2025
PubMed
Summary

Capecitabine enhances oxaliplatin effectiveness in advanced gastric cancer by increasing forkhead box P1 (FOXP1) expression. This combination therapy improves treatment outcomes and patient prognosis.

Keywords:
Advanced gastric cancerCapecitabineFOXP1GGTOxaliplatinSensitivity

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Area of Science:

  • Oncology
  • Medical Chemistry

Background:

  • Gastric cancer remains a significant global health challenge, particularly in its advanced stages.
  • Current treatment regimens often involve chemotherapy, but resistance and limited efficacy are common hurdles.

Purpose of the Study:

  • To evaluate the impact of capecitabine on oxaliplatin sensitivity in advanced gastric cancer.
  • To investigate the relationship between capecitabine, oxaliplatin, and the expression of forkhead box P1 (FOXP1) and gamma-glutamyl transpeptidase (GGT).

Main Methods:

  • Retrospective analysis of 152 advanced gastric cancer patients.
  • Comparison of oxaliplatin monotherapy (control) versus capecitabine plus oxaliplatin (study group).
  • Assessment of FOXP1 expression via immunohistochemistry, GGT levels by chemiluminescence, and protein analysis by Western blot.

Main Results:

  • The capecitabine plus oxaliplatin group showed a higher effective rate (94.74%) compared to oxaliplatin alone (76.32%).
  • Lower FOXP1 expression correlated with poorer overall survival (OS).
  • The combination therapy upregulated apoptosis-related molecules and downregulated DNA repair proteins, enhancing oxaliplatin's efficacy and improving 1-year and 3-year survival rates.

Conclusions:

  • Capecitabine significantly enhances gastric cancer cell sensitivity to oxaliplatin.
  • The combination therapy improves therapeutic outcomes and patient prognosis in advanced gastric cancer.
  • FOXP1 and GGT levels are identified as important prognostic factors for overall survival.