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Related Experiment Video

Updated: May 31, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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Surgery impairs glymphatic activity and cognitive function in aged mice.

Kai Chen1, Xingyu Du1, Melissa A Chao1

  • 1Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Molecular Brain
|January 25, 2025
PubMed
Summary
This summary is machine-generated.

Surgery worsens brain waste clearance in aging mice, impairing glymphatic function. This dysfunction may contribute to postoperative delirium in elderly patients and warrants further investigation into brain health after surgery.

Keywords:
Glymphatic systemIn vivo two-photon imagingPostoperative deliriumSurgery

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Area of Science:

  • Neuroscience
  • Gerontology
  • Surgical Research

Background:

  • Postoperative delirium is common in elderly surgical patients, increasing dementia risk.
  • Aging is a risk factor, but mechanisms of postoperative delirium are unclear.
  • The glymphatic system clears brain waste; its function declines with age and in neurodegeneration.

Purpose of the Study:

  • To investigate the impact of surgery on glymphatic system function in adult and aged mice.
  • To determine if surgery exacerbates age-related glymphatic impairment.
  • To correlate glymphatic function with cognitive performance after surgery.

Main Methods:

  • In vivo two-photon imaging to assess cerebrospinal fluid (CSF) tracer movement.
  • Comparison of glymphatic function in adult and aged mice 24 hours post-laparotomy versus sham surgery.
  • T-maze test to evaluate cognitive performance.

Main Results:

  • Adult mice showed no significant difference in glymphatic function between surgery and sham groups.
  • Aged mice exhibited delayed CSF tracer influx, with further impairment after surgery.
  • Glymphatic dysfunction in aged mice correlated with poorer T-maze performance.

Conclusions:

  • Surgery exacerbates glymphatic system impairment in aging brains.
  • Impaired glymphatic clearance may contribute to postoperative delirium in the elderly.
  • Findings highlight the link between surgical stress, brain waste clearance, and cognitive outcomes in aging.