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Updated: May 31, 2025
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Analysis of Factors Related to Early Left Ventricular Dysfunction in Hypertensive Patients with Preserved Ejection
Hoang M Tran1, Hung P Truong1, Cuong C Tran1
1Medicine Faculty, University of Medicine and Pharmacology at Ho Chi Minh City, Ho Chi Minh City 7000, Vietnam.
Insights
Hypertension patients with preserved ejection fraction can develop early left ventricular (LV) dysfunction. Diabetes, diastolic dysfunction, and LV hypertrophy are key predictors of abnormal global longitudinal strain (GLS).
Area of Science:
- Cardiology
- Echocardiography
- Hypertension Research
Background:
- Hypertension is a major risk factor for cardiovascular disease.
- Early detection of left ventricular (LV) dysfunction is crucial for managing hypertensive patients.
- Preserved ejection fraction (EF ≥ 50%) can mask subtle cardiac abnormalities.
Purpose of the Study:
- To identify factors associated with early left ventricular (LV) dysfunction in hypertensive patients with preserved ejection fraction.
- To investigate the role of speckle tracking echocardiography in assessing LV function.
- To correlate clinical and echocardiographic parameters with global longitudinal strain (GLS).
Main Methods:
- Cross-sectional study of 579 outpatients with hypertension.
- Utilized speckle tracking echocardiography to measure LV function and GLS.
- Collected and analyzed clinical data, including age, comorbidities, and cardiovascular risk factors.
Main Results:
- 45.25% of hypertensive patients exhibited LV diastolic dysfunction.
- 9.15% showed abnormal global longitudinal strain (GLS).
- Factors associated with abnormal GLS included age > 60, diabetes, concentric LV hypertrophy, concentric LV remodeling, and LV diastolic dysfunction (p < 0.05).
Conclusions:
- Diabetes, LV diastolic dysfunction, concentric hypertrophy, and concentric remodeling are significant predictors of abnormal GLS in hypertensive patients.
- These findings aid in the early identification and management of LV dysfunction.
- Speckle tracking echocardiography is valuable for assessing subclinical cardiac changes in hypertension.
Abstract:
Objective: The purpose of this research was to assess the factors linked to early left ventricular (LV) dysfunction in hypertensive patients who have preserved ejection fraction (EF ≥ 50%) using speckle tracking echocardiography. Methods: A cross-sectional study was carried out involving 579 outpatients recruited from City International Hospital in Ho Chi Minh City using a total sampling approach, where echocardiographic measurements and clinical data were gathered and analyzed. Results: The prevalence of LV diastolic dysfunction among hypertensive individuals was found to be 45.25%, with 9.15% showing abnormal global longitudinal strain (GLS). Factors such as being over the age of 60, having diabetes, concentric LV hypertrophy, concentric LV remodeling, and LV diastolic dysfunction were identified as correlating with abnormal GLS (p < 0.05). In contrast, other cardiovascular risk factors, including smoking and dyslipidemia, did not significantly influence the GLS index (p > 0.05). Conclusions: Key factors including diabetes, diastolic dysfunction, concentric hypertrophy, and concentric remodeling of the LV are significant predictors of abnormal GLS. These results are important for the management of hypertensive patients aimed at enhancing cardiac function.
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