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Updated: May 31, 2025

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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Dual Roles of Reducing Systems in Protein Persulfidation and Depersulfidation.

Zhichao Liu1, Nicolas Rouhier1,2, Jérémy Couturier1,2

  • 1Université de Lorraine, INRAE, IAM, F-54000 Nancy, France.

Antioxidants (Basel, Switzerland)
|January 25, 2025
PubMed
Summary

Hydrogen sulfide (H2S) signaling involves protein persulfidation, a key thiol modification. This review explores H2S pathways and the dual roles of thioredoxin and glutaredoxin systems in persulfidation and depersulfidation.

Keywords:
glutaredoxinglutathionehydrogen sulfideprotein persulfidationsulfurtransferasethioredoxin

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