Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Arteries of the Head and Neck

Arteries of the Head and Neck

The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

The Blood-brain Barrier

The Blood-brain Barrier

The Arch of Aorta

The Arch of Aorta

The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...

Overview of the Vascular System

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...

Anatomy of the Heart

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Innovations in Assist Devices to Improve External Ventricular Drain Placement: A Bibliometric Review of the Literature From 1985 to 2023.

Operative neurosurgery (Hagerstown, Md.)·2025

Same author

Risk factors related to traumatic spinal cord injury outcomes: An analysis of the US National Trauma Data Bank.

The journal of spinal cord medicine·2025

Same author

Applications of mixed reality with medical imaging for training and clinical practice.

Journal of medical imaging (Bellingham, Wash.)·2024

Same author

Tracheopathia osteochondroplastica: a case report illustrating the importance of imaging in this rare disorder.

AME case reports·2024

Same author

Prediction Models for Successful External Cephalic Version: An Updated Systematic Review.

American journal of perinatology·2023

Same author

Letter: Trends in In-Hospital Mortality and Neurological Deficit Rates Following Ischemic Stroke in Low- and Middle-Income Countries.

Neurosurgery·2023

Search research articles

Related Experiment Video

Updated: May 31, 2025

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts

Published on: June 28, 2024

Vascularization, Innervation, and Inflammation: Pathways Connecting the Heart-Brain Axis and Implications in a

Alexa R Lauinger¹, Joseph J Sepe²

¹Department of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

|January 25, 2025

Summary

The heart-brain axis describes the bidirectional relationship between the heart and brain. Understanding this connection, involving vascular, inflammatory, and neuromodulatory processes, is crucial for treating heart and brain diseases.

Keywords:

autonomic neuromodulation cardiovascular disease heart–brain axis stroke

More Related Videos

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

Published on: April 26, 2024

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

Related Experiment Videos

Last Updated: May 31, 2025

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts

Published on: June 28, 2024

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

Published on: April 26, 2024

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

Area of Science:

Neurocardiology
Cardiovascular Medicine
Neurology

Background:

Ischemic heart disease and stroke are leading global health issues.
These conditions share risk factors like hypertension, diabetes, and smoking.
The heart-brain axis highlights the intricate connection between cardiac and neurological health.

Purpose of the Study:

To summarize current research on the heart-brain axis.
To explore the vascular, neuromodulatory, and inflammatory mechanisms involved.
To inform future therapeutic and preventive strategies for heart and brain pathologies.

Main Methods:

Literature review of existing research on the heart-brain axis.
Analysis of physiological pathways connecting the heart and brain.
Synthesis of findings related to myocardial infarction and stroke.

Main Results:

The heart-brain axis involves complex interactions through vascular, neuromodulatory, and inflammatory pathways.
Dysfunction in one organ can lead to injury in the other, impacting long-term health.
Current understanding of these interactions is incomplete, necessitating further research.

Conclusions:

A comprehensive understanding of the heart-brain axis is vital for advancing neurocardiology.
This knowledge can guide the development of novel treatments for prevalent cardiovascular and neurological diseases.
Further research is proposed to elucidate these complex interactions and improve patient outcomes.