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TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses

Gilmara Barros de Lima1, Everton Nencioni1, Fábio Thimoteo1

  • 1Graduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, Brazil.

Biomolecules
|January 25, 2025
PubMed

Insights

Transmembrane serine protease 2 (TMPRSS2) aids viral entry and infection. Inhibitors targeting TMPRSS2 show promise for treating viral diseases like COVID-19 and potentially cancers.

Area of Science:

  • Biochemistry
  • Virology
  • Drug Discovery

Background:

  • TMPRSS2 is a human enzyme critical for the spread of viruses like influenza and coronaviruses.
  • It facilitates viral entry into host cells by cleaving viral glycoproteins, essential for pathogens such as SARS-CoV-2.
  • Genetic variations in TMPRSS2 influence susceptibility to infections like COVID-19, highlighting the importance of population diversity in research.

Purpose of the Study:

  • To review current TMPRSS2 inhibitors under investigation.
  • To explore the therapeutic potential of targeting TMPRSS2 in viral infections and cancer.

Main Methods:

  • Literature review of existing studies on TMPRSS2.
  • Analysis of ongoing clinical trials for TMPRSS2 inhibitors.

Main Results:

  • Several TMPRSS2 inhibitors are under investigation, with some progressing to clinical trials.
  • TMPRSS2's dual role in viral pathogenesis and cancer suggests broad therapeutic applicability.

Conclusions:

  • Targeting TMPRSS2 presents a promising strategy for developing novel antiviral therapies.
  • Further research into TMPRSS2's role in disease could lead to new treatments for infectious diseases and cancer.
Keywords:
TMPRSS2coronavirusinfluenzaserine proteinase inhibitors

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