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Characteristics of the First Italian Older Adults Vaccinated with an Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine

  • 0Hygiene Unit, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, 16132 Genoa, Italy.
Medicina +

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January 25, 2025

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January 25, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The first Italian adults vaccinated against respiratory syncytial virus (RSV) were older individuals with multiple health conditions. They showed high trust in vaccines and had received other routine immunizations, indicating readiness for RSV vaccination campaigns.

Area Of Science

  • Gerontology
  • Vaccinology
  • Public Health

Background

  • Three respiratory syncytial virus (RSV) vaccines are now available for older adults.
  • Understanding early vaccine uptake is crucial for successful vaccination campaigns.
  • The study focuses on the initial cohort of Italian recipients of an adjuvanted RSV vaccine.

Purpose Of The Study

  • To characterize the sociodemographic and clinical profiles of the first Italian users of the adjuvanted RSVPreF3 OA vaccine.
  • To explore their attitudes towards RSV and vaccination.
  • To assess their trust in vaccination.

Main Methods

  • A cross-sectional study conducted in Liguria, Italy, in 2024.
  • Participants were individuals aged 60 years and older eligible for the RSVPreF3 OA vaccine.
  • A questionnaire assessed sociodemographics, clinical history, attitudes toward RSV and vaccination, and vaccination trust.

Main Results

  • 453 individuals completed the survey, with a mean age of 74.9 years; 50.6% were male.
  • A high prevalence of comorbidities was observed (89.2%), notably cardiovascular conditions (70.4%).
  • High uptake of influenza (91.2%) and COVID-19 (98.7%) vaccines was reported. General practitioner advice was the primary driver for RSV vaccination (43.9%).
  • The average vaccination trust indicator (VTI) score was 91.5%, indicating high trust.
  • Positive attitudes toward RSV vaccination correlated with higher COVID-19 vaccine uptake and perceived personal risk.

Conclusions

  • The initial recipients of the RSVPreF3 OA vaccine in Italy were primarily high-risk individuals with comorbidities.
  • This group demonstrated high adherence to other routine vaccinations and strong trust in immunization.
  • Findings support targeted strategies for future RSV vaccination campaigns in older adults.

Keywords:

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