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Related Experiment Video

Updated: May 31, 2025

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
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Neohesperidin Mitigates High-Fat-Diet-Induced Colitis In Vivo by Modulating Gut Microbiota and Enhancing SCFAs

Kun Lu1, Sijie Shan1, Yanling Zeng2

  • 1National Engineering Laboratory for Rice and By-Products Processing, Food Science and Engineering College, Central South University of Forestry and Technology, Changsha 410004, China.

International Journal of Molecular Sciences
|January 25, 2025
PubMed
Summary

Neohesperidin (NHP) effectively reduces high-fat diet-induced colorectal inflammation in rats by modulating gut microbiota and promoting beneficial SCFAs. This natural compound offers a promising therapeutic strategy for inflammatory conditions.

Keywords:
JAK2/STAT3 pathwaySCFAsintestinal microbiotaintestinal mucosaneohesperidin

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Area of Science:

  • Gastroenterology
  • Nutrition Science
  • Pharmacology

Background:

  • High-fat diet (HFD) consumption is a known cause of colonic inflammation.
  • Neohesperidin (NHP), a citrus flavanone, exhibits anti-inflammatory properties, but its role in prolonged HFD-induced inflammation is not well understood.

Purpose of the Study:

  • To investigate the efficacy and underlying mechanisms of NHP in mitigating HFD-induced colorectal inflammation in a rat model.
  • To explore NHP's impact on intestinal microbiota composition and short-chain fatty acid (SCFA) production.

Main Methods:

  • Rats were fed an HFD and intragastrically administered NHP (40-80 mg/kg BW) for 12 weeks.
  • Colorectal inflammation markers (TNF-α, IL-1β), intestinal mucosal integrity, JAK2/STAT3 pathway, and intestinal microbiota were analyzed.
  • In vitro fecal fermentation was performed to assess SCFA production.

Main Results:

  • NHP administration significantly reduced colorectal inflammation markers and improved intestinal mucosal integrity.
  • NHP downregulated the Firmicutes/Bacteroidetes ratio and altered intestinal microbiota composition.
  • NHP intervention led to increased SCFA concentrations in fecal cultures.

Conclusions:

  • NHP demonstrates efficacy in reducing HFD-induced colorectal inflammation, potentially through the JAK2/STAT3 pathway.
  • NHP modulates gut microbiota and enhances SCFA production, contributing to its anti-inflammatory effects.
  • NHP, particularly at 80 mg/kg BW, is a promising natural compound for managing HFD-related colonic inflammation.