Predictive Value of Selected Plasma Biomarkers in the Assessment of the Occurrence and Severity of Coronary Artery Disease
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View abstract on PubMed
Summary
This summary is machine-generated.Interleukin-8 (IL-8) shows potential as a biomarker for coronary artery disease (CAD). Higher IL-8 levels correlate with CAD presence and severity, suggesting its use in diagnosing atherosclerosis.
Area Of Science
- Cardiovascular Medicine
- Biomarker Discovery
- Diagnostic Imaging
Background
- Coronary artery disease (CAD) diagnosis relies on imaging, but novel approaches are needed.
- Circulating biomarkers offer a promising alternative for CAD detection.
- Cytokines, cell adhesion molecules, and enzymes are potential diagnostic markers.
Purpose Of The Study
- To investigate the correlation between plasma biomarker levels and CAD presence/severity.
- To evaluate interleukin-6 (IL-6), interleukin-8 (IL-8), soluble vascular cell adhesion molecule-1 (sVCAM-1), endothelin-1 (ET-1), and ADAMTS-1 in CAD patients.
Main Methods
- 40 patients undergoing coronary angiography were enrolled.
- CAD defined as coronary artery stenosis ≥ 50%.
- Gensini Score (GS) assessed CAD severity. Plasma biomarker levels were measured.
Main Results
- IL-8 levels were significantly higher in patients with CAD (p=0.0228).
- No significant differences found for other biomarkers (IL-6, sVCAM-1, ET-1, ADAMTS-1).
- Positive correlation between IL-8 and Gensini Score (ρ=0.39, p=0.017).
Conclusions
- IL-8 may serve as an additional diagnostic tool for atherosclerosis.
- Elevated IL-8 levels are associated with CAD presence and severity.
- Further research with larger cohorts is required to confirm clinical utility.
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