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Enhancing the Solubility and Dissolution of Apigenin: Solid Dispersions Approach
Natalia Rosiak1, Ewa Tykarska2, Andrzej Miklaszewski3
1Department of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland.
International Journal of Molecular Sciences
|January 25, 2025
Summary
This study enhanced apigenin (APG) solubility using solid dispersions with Pluronic F-127 (PLU127). APG-PLU127 showed improved solubility and antioxidant activity, highlighting its potential for oral drug delivery.
Area of Science:
- Pharmacology and Pharmaceutics
- Materials Science
Background:
- Apigenin (APG), a flavonoid, has therapeutic potential but poor water solubility limits bioavailability.
- Solid dispersions offer a strategy to overcome poor drug solubility and enhance therapeutic efficacy.
Purpose of the Study:
- To improve the solubility and bioavailability of apigenin (APG) using solid dispersions.
- To evaluate the performance of different polymeric excipients, focusing on Pluronic F-127 (PLU127), for APG delivery.
Main Methods:
- Solid dispersions of APG were prepared using ball milling with various polymers, including Pluronic F-127 (PLU127).
- Solubility, dissolution rates, molecular interactions (DSC, FT-IR), stability, and antioxidant activity (ABTS assay) were assessed.
Main Results:
- APG-PLU127 dispersions demonstrated significantly enhanced solubility at various pH values (1.2, 5.5, 6.8).
- Molecular interactions confirmed by DSC and FT-IR contributed to improved solubility and dissolution.
- APG-PLU127 maintained substantial antioxidant activity after one year of storage, despite minor solubility changes.
Conclusions:
- Pluronic F-127 (PLU127) is a superior carrier for enhancing apigenin (APG) solubility, release, and antioxidant activity.
- APG-PLU127 solid dispersions show promise for developing effective oral dosage forms.
- The formulation strategy effectively addresses the bioavailability challenges of apigenin.
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