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Long Non-Coding RNAs in Malignant Human Brain Tumors: Driving Forces Behind Progression and Therapy
Dakun Pei1, Dandan Zhang1, Yan Guo1
1State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing 400715, China.
Abstract:
Long non-coding RNAs (lncRNAs) play a pivotal role in regulating gene expression and are critically involved in the progression of malignant brain tumors, including glioblastoma, medulloblastoma, and meningioma. These lncRNAs interact with microRNAs (miRNAs), proteins, and DNA, influencing key processes such as cell proliferation, migration, and invasion. This review highlights the multifaceted impact of lncRNA dysregulation on tumor progression and underscores their potential as therapeutic targets to enhance the efficacy of chemotherapy, radiotherapy, and immunotherapy. The insights provided offer new directions for advancing basic research and clinical applications in malignant brain tumors.
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