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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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MicroRNA-200c in Cancer Generation, Invasion, and Metastasis.

Honghao Guo1, Ning Zhang1, Tao Huang1

  • 1Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.

International Journal of Molecular Sciences
|January 25, 2025
PubMed
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MicroRNA-200c (miR-200c) is a key regulator in cancer development, impacting tumor growth, spread, and patient outcomes. This review explores its role and potential as a cancer biomarker and therapeutic target.

Keywords:
invasionmetastasismicroRNA-200ctumorigenesis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • MicroRNA-200c (miR-200c) is a small RNA molecule with significant roles in cancer.
  • It influences critical processes such as tumor development, invasion, and metastasis.

Purpose of the Study:

  • To review the expression and functions of miR-200c in various cancers.
  • To explore its potential as an early detection biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on miR-200c in cancer.
  • Synthesis of research on miR-200c's regulatory roles in cell proliferation, apoptosis, and epithelial-mesenchymal transition (EMT).

Main Results:

  • miR-200c regulates key cancer progression mechanisms including EMT, proliferation, and migration.
  • Altered miR-200c expression is observed across diverse tumor types.

Conclusions:

  • miR-200c is a crucial regulator in tumor biology with potential clinical applications.
  • Further research into miR-200c could enhance cancer diagnostics and targeted therapies.