Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer.
Chien-Yu Huang1,2, Ren-Hao Xie1,2, Pin-Hsuan Li2
1Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
International Journal of Molecular Sciences
|January 25, 2025
Summary
Bisphenol A (BPA) exposure may promote papillary thyroid cancer (PTC) progression by increasing invasiveness and reducing differentiation. This study used 3D models to show BPA
Area of Science:
- Endocrinology
- Environmental Health
- Oncology
Background:
- Bisphenol A (BPA) is a widespread environmental contaminant with endocrine-disrupting properties.
- The effects of BPA on papillary thyroid cancer (PTC) progression under realistic conditions are not fully understood.
Purpose of the Study:
- To investigate the impact of environmentally relevant BPA concentrations on PTC progression.
- To utilize a 3D thyroid papillary tumor spheroid model for enhanced biological relevance.
Main Methods:
- Exposure of PTC cells to BPA in a 3D tumor spheroid model.
- Analysis of key markers including E-cadherin, vimentin, and thyroglobulin (TG) secretion.
- Assessment of epithelial-mesenchymal transition (EMT) and cell differentiation.
Main Results:
- BPA exposure led to decreased E-cadherin and increased vimentin expression, suggesting promotion of EMT.
- Reduced thyroglobulin (TG) secretion was observed, indicating decreased cell differentiation.
- BPA exposure may enhance PTC invasiveness and radioiodine therapy resistance.
Conclusions:
- BPA at environmental concentrations can negatively impact PTC progression.
- 3D tumor spheroid models are valuable for assessing chemical risks in complex biological systems.
- Findings underscore the environmental risks of BPA concerning thyroid cancer and endocrine disruption.
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