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Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents
Domenico Iacopetta1, Alessia Catalano2, Jessica Ceramella1
1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
Molecules (Basel, Switzerland)
|January 25, 2025
Summary
Chitosan-based Schiff bases (CSBs) show significant antimicrobial properties, offering potential solutions against rising antimicrobial resistance (AMR). This review highlights CSBs and their metal complexes, focusing on their effectiveness against drug-resistant infections.
Area of Science:
- Biochemistry
- Materials Science
- Medicinal Chemistry
Background:
- Chitosan modification enhances solubility and applications.
- Schiff bases are versatile scaffolds with diverse biological activities.
- Antimicrobial resistance (AMR) is a critical global health threat.
Purpose of the Study:
- To review the biological activities of chitosan-based Schiff bases (CSBs).
- To focus on the antimicrobial properties of CSBs and their metal complexes.
- To highlight recent literature on CSBs in combating AMR.
Main Methods:
- Literature review of scientific articles on CSBs.
- Analysis of studies detailing the synthesis and characterization of CSBs.
- Evaluation of reported biological and catalytic activities, with emphasis on antimicrobial effects.
Main Results:
- CSBs exhibit a wide range of biological activities, including anticancer, anti-inflammatory, and antioxidant properties.
- CSBs demonstrate significant antimicrobial effects against various pathogens.
- Metal complexes of CSBs often show enhanced biological activities, including potent antimicrobial action.
Conclusions:
- CSBs are promising candidates for developing new antimicrobial agents.
- Further research into CSBs and their metal complexes could lead to novel treatments for AMR.
- CSBs offer a valuable platform for addressing the challenge of antimicrobial resistance.
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