Related Experiment Video
Updated: Jun 26, 2026
07:53
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
Published on: April 26, 2016
11.1K
Continuous Production of Docetaxel-Loaded Nanostructured Lipid Carriers Using a Coaxial Turbulent Jet Mixer with
Hyeon Su Lim1, Won Il Choi2, Jong-Min Lim1,3
1Department of Electronic Materials, Devices, and Equipment Engineering, Soonchunhyang University, 22 Soonchunhyang-ro, Shinchang-myeon, Asan-si 31538, Chungcheongnam-do, Republic of Korea.
Molecules (Basel, Switzerland)
|January 25, 2025
Summary
High throughput production of nanostructured lipid carriers (NLCs) was achieved using a coaxial turbulent jet mixer. This method yields smaller, more uniform NLCs ideal for drug delivery, outperforming traditional nanoprecipitation.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmaceutical Sciences
Background:
- Continuous synthesis of nanoparticles (NPs) offers reproducible control over physicochemical properties.
- Nanostructured lipid carriers (NLCs) are promising for drug delivery applications.
- Existing methods for NLC production can be limited in scalability and uniformity.
Purpose of the Study:
- To develop a high throughput method for producing nanostructured lipid carriers (NLCs) with controllable properties.
- To investigate the use of a coaxial turbulent jet mixer with a heating system for NLC synthesis.
- To compare the characteristics of NLCs produced by the new method with those from bulk nanoprecipitation.
Main Methods:
- Utilized a coaxial turbulent jet mixer with a heating system for continuous NLC synthesis.
- Investigated the influence of Reynolds number (Re) and lipid concentration on NLC size.
- Employed a precursor solution and non-solvent crossflow design for efficient dissolution of lipids and surfactants.
Main Results:
- Achieved high throughput production of NLCs with tunable sizes around 80 nm.
- Demonstrated size controllability of NLCs based on Reynolds number and lipid concentration.
- NLCs produced via coaxial turbulent jet mixing exhibited smaller size, uniform distribution, and higher drug loading compared to bulk nanoprecipitation.
Conclusions:
- The coaxial turbulent jet mixer provides an efficient and scalable method for NLC synthesis.
- Optimized NLCs are suitable for targeted drug delivery via the enhanced permeability and retention (EPR) effect.
- This technology advances nanomedicine by enabling superior NLC production for pharmaceutical applications.
