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Modified M-K medium for human penetrating keratoplasty
Transactions of the Ophthalmological Societies of the United Kingdom
|April 1, 1979
Summary
This study modified McCarey-Kaufman medium for corneal transplants. The enhanced medium resulted in excellent graft survival and clarity after one year.
Area of Science:
- Ophthalmology
- Transplantation immunology
- Biomaterials science
Background:
- Corneal transplantation, or penetrating keratoplasty, is a common procedure to restore vision.
- Graft survival and clarity are critical outcomes influenced by preservation media.
- The McCarey-Kaufman (M-K) medium is a standard preservation solution.
Purpose of the Study:
- To evaluate the efficacy of a modified McCarey-Kaufman (M-K) medium for human penetrating keratoplasty.
- To assess graft survival and clarity rates using the altered M-K medium.
Main Methods:
- A series of 120 consecutive human penetrating keratoplasties were performed.
- The McCarey-Kaufman (M-K) medium was modified by altering the buffer system, incorporating a pH indicator, and using a different antibiotic.
- Graft outcomes were monitored for primary donor failure and graft clarity at 1 year.
Main Results:
- No cases of primary donor failure were observed in the 120 procedures.
- A 95% clear graft survival rate was achieved after 1 year.
- The modified M-K medium demonstrated successful tissue preservation and support for corneal grafts.
Conclusions:
- The modified McCarey-Kaufman (M-K) medium is effective for human penetrating keratoplasty.
- The alterations to the M-K medium support excellent graft survival and clarity.
- This modified medium represents a viable option for corneal preservation in transplantation.