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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Comprehensive Review of Lipid Management in Chronic Kidney Disease and Hemodialysis Patients: Conventional

Erica Abidor1, Michel Achkar1, Ibrahim Al Saidi1

  • 1Department of Medicine, Northwell Health, Staten Island University Hospital, Staten Island, NY 10305, USA.

Journal of Clinical Medicine
|January 25, 2025
PubMed

Insights

Lipid disorders are common in kidney disease patients, increasing cardiovascular risk. Current lipid-lowering therapies show limited benefits, especially in dialysis patients, necessitating further research for tailored strategies.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Dyslipidemia is highly prevalent in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD).
  • These lipid disorders significantly elevate cardiovascular risk in affected individuals.
  • Effective management of dyslipidemia is crucial for improving outcomes in CKD and ESKD populations.

Purpose of the Study:

  • To review the effectiveness of various lipid-lowering agents in patients with CKD and ESKD.
  • To identify current gaps in research regarding lipid management in these high-risk groups.
  • To assess the impact of lipid-lowering therapies on cardiovascular risk in CKD and ESKD.

Main Methods:

  • A comprehensive literature search was performed across Embase, PubMed, Cochrane, and Google Scholar.
  • Keywords included terms such as chronic kidney diseases, dialysis, dyslipidemia, statins, and ezetimibe.
  • Findings from relevant studies were synthesized to provide an overview of current dyslipidemia management.

Main Results:

  • Statins demonstrated mixed results in CKD and ESKD, with limited cardiovascular event reduction in dialysis patients.
  • PCSK9 inhibitors show promise but require additional investigation.
  • Non-statin therapies like fibrates and omega-3 fatty acids have insufficient evidence for widespread use.

Conclusions:

  • Further research is essential to optimize lipid-lowering strategies for CKD and ESKD patients.
  • Tailored lipid management approaches are needed, considering the unique risk factors of vulnerable populations.
  • Future studies should explore the role of exercise and risk calculators in managing cardiovascular outcomes.

Keywords:
chronic kidney diseasedyslipidemiahemodialysisstatins

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