Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

106
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
106

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leptin-specific epigenetic modulation of preterm cord blood serves as a candidate biomarker for obesity.

Pediatric research·2026
Same author

Fatty Acids and Their Roles in Cardiac Physiology and Pathology: Mechanistic and Interventional Studies.

Nutrients·2026
Same author

Genome Editing Technologies for Cancer Therapy.

Current gene therapy·2026
Same author

Nanoformulated Phytochemicals Against Pancreatic Cancer: Emerging Advances in Therapeutic Strategies.

International journal of nanomedicine·2026
Same author

Differential Expression of Key Oncogenic and Tumor Suppressor MicroRNAs Induced by Andrographolide in Androgen-Independent PC3 and Androgen-Dependent LNCaP Prostate Cancer Cells.

Genes·2025
Same author

Intra-Articular Delivery of Nanoemulsified Curcumin Ameliorates Joint Degeneration in a Chemically Induced Model of Osteoarthritis.

International journal of molecular sciences·2025

Related Experiment Video

Updated: May 30, 2025

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.6K

Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies.

Rahul Mallick1, Sanjay Basak2, Premanjali Chowdhury3

  • 1A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.

Pharmaceuticals (Basel, Switzerland)
|January 25, 2025
PubMed
Summary

Targeting brain inflammation from cytokines shows promise for treating neurological disorders. Novel therapies offer hope for improved specificity and safety in CNS treatments.

Keywords:
biomarkers in neuroinflammationbrain disorders therapycytokine-mediated neuroinflammationpro-inflammatory cytokinestargeted drug delivery

More Related Videos

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

15.8K
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

34.9K

Related Experiment Videos

Last Updated: May 30, 2025

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.6K
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

15.8K
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

34.9K

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Cytokine-mediated inflammation is crucial in brain disorders like neurodegenerative and psychiatric conditions.
  • Pro-inflammatory cytokines (IL-1, TNF-α, IL-6) drive neuroinflammation, impair brain function, and worsen disease.
  • Current treatments for brain inflammation are limited due to challenges like the blood-brain barrier (BBB).

Purpose of the Study:

  • To review emerging therapeutic strategies for cytokine-driven neuroinflammation.
  • To focus on advances targeting specific cytokines in brain pathology.
  • To explore novel approaches for treating CNS inflammatory disorders.

Main Methods:

  • Review of current literature on cytokine-specific inhibitors, antibody-based therapeutics, and gene/RNA-based interventions.
  • Analysis of advanced drug delivery systems, including nanoparticles, for CNS targeting.
  • Examination of progress in biomarker discovery and neuroimaging for monitoring inflammation.

Main Results:

  • Novel therapies like cytokine inhibitors and nanocarriers demonstrate potential for targeted neuroinflammation reduction.
  • Biomarkers and advanced imaging aid in personalized treatment strategies.
  • Preclinical and clinical data support the therapeutic efficacy of these tailored approaches.

Conclusions:

  • Targeted therapies offer greater specificity and safety for managing neuroinflammation compared to traditional drugs.
  • Overcoming BBB penetration and off-target effects are key challenges for widespread clinical application.
  • Personalized, cytokine-centered treatments could revolutionize brain disorder therapy, improving patient outcomes.