Related Experiment Video
Updated: May 30, 2025
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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The Interplay Between Gut Microbiota, Adipose Tissue, and Migraine: A Narrative Review
Valentina Biagioli1, Federica Mela2, Paola Ferraro2
1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16126 Genoa, Italy.
Nutrients
|January 25, 2025
Summary
Migraine may be influenced by gut bacteria and body fat. Targeting the gut-brain axis and adipose tissue with diet and supplements shows promise for managing migraine.
Area of Science:
- Neuroscience
- Microbiology
- Metabolic Science
Background:
- Migraine is a common neurovascular disorder with substantial global impact.
- Gut microbiota and adipose tissue are increasingly recognized as key modulators of migraine pathophysiology.
- Mechanisms involve neuroinflammation and metabolic dysregulation.
Purpose of the Study:
- To review the current literature on the interplay between gut microbiota, adipose tissue, and migraine.
- To explore the role of dietary interventions in modulating these relationships.
- To synthesize findings on the gut-brain axis in migraine.
Main Methods:
- A narrative review of studies published between 2000 and 2024.
- Literature search conducted using the PubMed database.
- Analysis of studies examining microbiota, adipose tissue, and migraine, including dietary impacts.
Main Results:
- A bidirectional gut-brain axis exists, with gut microbiota influencing neuroinflammation via metabolites like short-chain fatty acids (SCFAs).
- Obesity worsens migraine through chronic inflammation and dysregulated adipocytokines (leptin, adiponectin).
- Dietary patterns (low glycemic index, Mediterranean) and microbial interventions (prebiotics, probiotics, postbiotics) show therapeutic potential.
Conclusions:
- Integrative therapeutic strategies targeting the microbiota-gut-brain axis and adipose tissue are crucial for migraine management.
- Future research should focus on longitudinal studies and personalized interventions for optimized migraine treatment outcomes.
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