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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

113
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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173
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Selective Laser Sintering 3D Printing of Carvedilol Tablets: Enhancing Dissolution Through Amorphization.

Nikola Pešić1, Branka Ivković2, Tanja Barudžija3

  • 1Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.

Pharmaceutics
|January 25, 2025
PubMed
Summary

Selective laser sintering (SLS) 3D printing effectively converts poorly soluble drugs like carvedilol into an amorphous state. This process significantly enhances drug dissolution rates and bioavailability for improved pharmaceutical formulations.

Keywords:
3D printingamorphous statedissolution improvementpoorly soluble drugsselective laser sintering

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery Systems

Background:

  • Selective laser sintering (SLS) is a promising 3D printing technique for pharmaceuticals.
  • SLS enables solvent-free fabrication of porous dosage forms with high drug loading.
  • Elevated temperatures during SLS can induce crystalline-to-amorphous drug conversion, enhancing solubility.

Purpose of the Study:

  • To investigate SLS 3D printing for fabricating carvedilol tablets.
  • To improve the dissolution rate of poorly soluble carvedilol by inducing amorphization.
  • To assess the potential of SLS in enhancing the bioavailability of poorly water-soluble drugs.

Main Methods:

  • Eight carvedilol tablet formulations were produced using SLS 3D printing.
  • Two powder mixtures and four experimental condition combinations were tested.
  • Tablets underwent physicochemical characterization and dissolution testing.

Main Results:

  • Physicochemical analysis confirmed partial amorphization of carvedilol during SLS printing.
  • Higher printing temperatures and lower laser speeds promoted greater amorphization.
  • The amorphous form of carvedilol exhibited significantly improved dissolution compared to its crystalline state.

Conclusions:

  • SLS 3D printing is an effective method for converting poorly water-soluble drugs to amorphous forms.
  • This technique can enhance drug solubility and bioavailability.
  • SLS offers a viable strategy for developing advanced pharmaceutical dosage forms.