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Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability
Eleonora Truzzi1, Giulia Vanti2, Lucia Grifoni2
1Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
Pharmaceutics
|January 25, 2025
Summary
Natural resins show therapeutic potential but face challenges with solubility and bioavailability. Nanovectors effectively enhance resin delivery and therapeutic efficacy, paving the way for advanced wound healing therapies.
Area of Science:
- Natural Products Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Resins, complex natural mixtures, possess historical medicinal value and diverse therapeutic activities.
- Key limitations for clinical resin use include poor water solubility, stability, and bioavailability.
- Nanotechnology offers potential solutions to overcome these limitations in resin formulations.
Purpose of the Study:
- To review the application of nanovectors for improving the biopharmaceutical properties of resins.
- To evaluate the efficacy of nanovectors in enhancing resin delivery and therapeutic outcomes.
- To explore the potential of resins and nanovectors in advanced therapeutic applications, such as wound healing.
Main Methods:
- Investigated various nanovectors: vesicles, solid lipid nanoparticles, micelles, nanoemulsions, microemulsions, and mesoporic nanoparticles.
- Assessed the ability of nanovectors to encapsulate resins and their components.
- Evaluated modifications in release properties, cellular uptake, and biological barrier penetration.
Main Results:
- Developed nanovectors successfully entrapped significant amounts of resins and their constituents.
- Nanovector formulations demonstrated modified release profiles and enhanced cellular uptake.
- Improved penetration across biological barriers and optimized biopharmaceutical properties were observed.
- Resins acted as penetration enhancers, optimizing nanovector design for barrier circumvention.
Conclusions:
- Nanovectors significantly enhance the biopharmaceutical properties of natural resins.
- These systems show promise for optimizing the delivery and efficacy of resins for therapeutic applications.
- Nanovectors represent a powerful platform for developing novel resin-based therapies, particularly for wound healing.
Keywords:
Boswellia and CommiphoraCopaiferaDracaenaFerulaPinus and PiceaPistaciaactive or nanocarrier-forming constituentsenhanced stability and bioavailabilitynanovectorsplant resins and their essential oilsMore Related Videos
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