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Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery.
Adila Nazli1, Milo Malanga2, Tamás Sohajda2
1Department of Pharmacognosy, Semmelweis University, 1085 Budapest, Hungary.
Pharmaceutics
|January 25, 2025
Summary
Cationic cyclodextrins offer advanced drug and nucleic acid delivery by enhancing cell membrane permeability and condensation. This review details their design, therapeutic applications, and potential for multimodal systems.
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Nanotechnology
Background:
- Cyclodextrins are versatile hosts for payload delivery via inclusion complexes and surface functionalization.
- Cationic cyclodextrins enhance drug permeability across cell membranes and condense nucleic acids through electrostatic interactions.
Purpose of the Study:
- To review recent advances in cationic cyclodextrin-based delivery systems.
- To analyze their chemistry, drug release, and therapeutic outcomes for various drug classes and nucleic acids.
Main Methods:
- Identification of common cationic moieties for cyclodextrin design.
- Analysis of drug delivery systems for anticancer, anti-inflammatory, antibacterial, and antidiabetic agents.
- Evaluation of nucleic acid delivery systems against commercial vectors (PEI 25 kDa, Lipofectamine 2000).
Main Results:
- Cationic cyclodextrins demonstrate improved complexation and therapeutic efficacy.
- Effective delivery of both small molecule drugs and nucleic acids was observed.
- Potential for multimodal systems combining drug and nucleic acid delivery was highlighted.
Conclusions:
- Cationic cyclodextrins represent a promising platform for advanced drug and nucleic acid delivery.
- Further research is needed to address challenges and limitations for clinical translation.
