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Chordoma Spontaneous Regression After COVID-19
Luis Fernando Moura da Silva Junior1, Gyl Eanes Barros Silva1, Marcos Adriano Garcia Campos2
1University Hospital of UFMA, Federal University of Maranhao, São Luís 65080-805, Maranhão, Brazil.
Viruses
|January 25, 2025
Summary
This study reports the first case of a chordoma tumor spontaneously regressing after a COVID-19 infection. The findings suggest that T-cells, activated by SARS-CoV-2, may enhance anti-tumor immunity against chordoma.
Area of Science:
- Oncology
- Immunology
- Virology
Background:
- Chordomas are slow-growing sarcomas with a propensity for local invasion and metastasis.
- Spontaneous tumor regression is rare, especially in chordoma.
- The interaction between viral infections and anti-tumor immunity is an emerging area of research.

