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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Related Experiment Video

Updated: May 30, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
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Gene Therapy for Glioblastoma Multiforme.

Smit Shah1, Joshua Green2, Shantelle A Graff2

  • 1Neurology Department, School of Medicine, University of South Carolina, 15 Medical Park Rd., Columbia, SC 29203, USA.

Viruses
|January 25, 2025
PubMed
Summary

Gene therapy offers a novel approach to combat aggressive glioblastoma multiforme (GBM) by genetically modifying tumor cells to reduce growth and boost immunity. This review explores viral and nonviral vectors for advanced GBM treatment strategies.

Keywords:
geneglioblastomasurvivaltherapyvector

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Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Glioblastoma multiforme (GBM) is an aggressive brain tumor with a <10% five-year survival rate.
  • Current GBM treatments face challenges like poor drug delivery across the blood-brain barrier, drug resistance, and genetic complexity.
  • Gene therapy presents a distinct mechanism to potentially overcome these limitations.

Purpose of the Study:

  • To review current advancements in gene therapy for glioblastoma multiforme.
  • To discuss various viral and nonviral vectors and their genetic payloads for GBM treatment.
  • To explore the oncolytic and immunogenic effects of gene therapy agents in GBM.

Main Methods:

  • Review of scientific literature on gene therapy applications in glioblastoma.
  • Analysis of viral and nonviral vectors used for gene delivery.
  • Examination of DNA transgenes and RNA inhibitors for anti-GBM therapy.

Main Results:

  • Gene therapy utilizes diverse vectors and genetic cargoes to modify GBM cells.
  • Oncolytic and immunogenic effects of gene therapy agents show promise for GBM treatment.
  • Combination of gene therapy with standard treatments may enhance therapeutic outcomes.

Conclusions:

  • Gene therapy represents a promising therapeutic avenue for glioblastoma multiforme.
  • Further research into optimized vectors and genetic payloads is crucial.
  • Investigating combination therapies could significantly improve GBM patient survival rates.