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Synthesis of 1,4-Diketones from Esters Enabled by a Tetraborylethane Reagent
Miaomiao Wu1,2, Tongchang Fang2, Liangxuan Xu2
1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Abstract:
A modular synthesis method for 1,4-diketones has been developed. Utilizing inexpensive carboxylic acid esters as carbonyl sources and tetraborylethane (TBE) as a nucleophilic reagent, a one-pot strategy for constructing two C-C bonds was established. Notably, this reaction proceeds without the involvement of transition metals and exhibits excellent functional group compatibility. A diverse array of α-substituted 1,4-diketones were synthesized using various electrophiles for capture.
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