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Updated: May 30, 2025

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
Published on: July 12, 2024
Ambient coarse particulate matter pollution and hospital admissions for schizophrenia
Yating Ma1, Lijun Bai2, Yunxing Jiang2
1Institute of Social Psychology, School of Humanities and Social Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Objective:
To investigate the association between ambient coarse particulate matter (PM2.5-10) pollution and risk of acute schizophrenia episodes.
Methods:
A time-stratified case-crossover study with a two-stage analytical approach was conducted to investigate the association between ambient PM2.5-10 pollution and schizophrenia admissions (an indicator for acute schizophrenia episodes) across 259 Chinese cities of prefecture-level or above during 2013-2017. A conditional logistic regression model was constructed to estimate city-specific changes in hospital admissions for schizophrenia associated with per interquartile range (IQR) increase in ambient PM2.5-10, and the overall associations were obtained by pooling the city-specific associations using the random-effects model.
Results:
A total of 817,296 schizophrenia admissions were included in the analysis. Per IQR increase (28.43 μg/m3) in PM2.5-10 at lag01 was associated with an increase of 1.66 % (95 % CI: 0.68 %, 2.65 %) in schizophrenia admissions. Compared to concentrations <30 μg/m3, PM2.5-10 concentrations of 30-49 μg/m3 and ≥50 μg/m3 were associated with increases of 2.25 % (95 % CI: 0.73 %%, 3.79 %) and 4.03 % (95 % CI: 1.92 %, 6.18 %) in schizophrenia admissions, respectively. City-level urbanization has the potential to attenuate the association between ambient PM2.5-10 and schizophrenia admissions (P = 0.0002).
Conclusions:
Our study provides novel evidence for the acute adverse effects of ambient PM2.5-10 on schizophrenia and calls for special attention on the control of high PM2.5-10 pollution in disease prevention.
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