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Published on: April 15, 2013
Investigating the stability of chalcone (2E)-1-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one by Raman
R C de Oliveira1, A J Barros2, G V S Mota2
1Institute of Exact and Naturals Sciences, Federal University of Pará, 66075-110 Belém, PA, Brazil; College of Application (CAp), Federal University of Roraima, 69310-000 Boa Vista, RR, Brazil.
Abstract:
Chalcones are organic substances that have diverse biological activities and exhibit potential for the treatment of various diseases. The properties of these substances depend on the type and position of the functional group attached to their aromatic rings. As a result, in this work the chalcone (2E)-1-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one (C16H14O3) was investigated by Raman spectroscopy and computational calculations at high pressures with the objective of analyzing its structural stability. Slight changes occur in the Raman spectra, mainly associated with the vibrational modes involving the hydroxyphenyl, methoxyphenyl rings and the hydroxy and methoxy groups, in addition to variations in the C-H∙∙∙O hydrogen bonds between 3 and 4 GPa and between 7 and 8 GPa. These small changes in the structure indicate that this chalcone is quite stable at pressures up to 10 GPa. The Raman spectra obtained during decompression show that such changes are reversible across the entire spectral range investigated.
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