Bioavailability studies with ciglitazone in beagles. I. Effect of a meal on the bioavailability of three ciglitazone dosage forms

Three separate Latin square crossover studies were conducted in beagles to examine the effect of a meal on the bioavailability of a ciglitazone tablet, suspension, and solution. In these studies, drug was administered to fasted animals with either 50 ml water or with 180 g Purina Dog Chow and 20 g butter. The data indicated that the meal significantly increased the AUC by about 40 per cent for both the tablet and the suspension but had no significant effect on the solution treatment. Comparisons across studies indicated low bioavailability in fasted animals from either the tablet or suspension relative to the solution. When drug was co-administered with a meal, however, bioavailability appeared to be independent of dosage form.