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Updated: May 30, 2025

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

Data Collection Variability Across Neonatal Hypoxic-Ischemic Encephalopathy Registries.

Eric S Peeples¹, Ulrike Mietzsch², Eleanor Molloy³

¹Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE; Division of Neonatology, Children's Nebraska, Omaha, NE; Child Health Research Institute, Omaha, NE.

The Journal of Pediatrics

|January 25, 2025

Summary

This summary is machine-generated.

Global neonatal hypoxic-ischemic encephalopathy (HIE) registries show significant data variability. Harmonizing standard common data elements is crucial for improving HIE management and outcomes worldwide.

Keywords:

common data elements harmonization perinatal asphyxia therapeutic hypothermia

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Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

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Published on: March 14, 2013

Area of Science:

Neonatal neurology
Clinical data management
Global health initiatives

Background:

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of brain injury in newborns.
Numerous HIE data registries exist globally, collecting diverse patient information.
Lack of standardized data hinders comparative analysis and collaborative research.

Purpose of the Study:

To evaluate the heterogeneity of data elements across international neonatal HIE registries.
To identify the necessity for standardizing common data elements for global HIE research.

Main Methods:

Cross-sectional analysis of data collection forms from 22 HIE registries across 14 countries.
Identification of registries through literature review and investigator outreach.
Categorization of abstracted data elements by expert consensus.

Main Results:

1281 data elements were analyzed, with a median of 106.5 elements per registry.
Pregnancy, therapeutic hypothermia, and short-term outcomes were commonly collected.
Laboratory values (excluding acid/base) and neurodevelopmental follow-up data showed significant variability.
Only 4 variables were uniformly collected across all registries.

Conclusions:

Existing neonatal HIE registries exhibit substantial variation in data collection scope and format.
Developing standardized common data elements is essential for global HIE data harmonization.
Standardization will facilitate international collaboration to optimize HIE patient management and outcomes.