Clonal hematopoiesis of indeterminate potential and cardiovascular diseases: A review

Area of Science:

• Genetics and Cardiology
• Hematology and Cardiovascular Medicine

Background:

• Cardiovascular disease (CVD) is a leading global cause of death.
• Established CVD risk factors include dyslipidemia, smoking, diabetes, hypertension, and obesity.
• Overlapping genetic links between other diseases and cardiovascular health are increasingly recognized.

Purpose of the Study:

• To explore the association between clonal hematopoiesis of intermediate potential (CHIP) and cardiovascular diseases (CVD).
• To highlight the potential of targeting CHIP pathways for reducing residual cardiovascular risk.

Main Methods:

• Review of studies identifying mutations (e.g., TET2, DNMT3A, ASXL1, JAK2) causing CHIP.
• Analysis of epidemiological data linking CHIP mutations to specific cardiovascular conditions.

Main Results:

• CHIP, characterized by specific gene mutations, is associated with age-related hematological conditions.
• CHIP mutations are linked to increased risks of coronary artery disease, heart failure, aortic stenosis, and arrhythmias.
• Addressing the CHIP-CVD link presents an opportunity to mitigate cardiovascular risk.

Conclusions:

• The association between CHIP and CVD warrants further investigation.
• Therapeutic strategies targeting inflammasomes, interleukin pathways, or CHIP mutations may offer novel approaches for CVD management.