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Updated: May 30, 2025

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
Published on: January 5, 2024
Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat
Ruwani L Wimalasekara1, Dawn White1, Ayush Kumar2
1Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Abstract:
Regulatory elements controlling gene expression fine-tune bacterial responses to environmental cues, including antimicrobials, to optimize survival. Acinetobacter baumannii, a pathogen notorious for antimicrobial resistance, relies on efficient efflux systems. Though the role of efflux systems in antibiotic expulsion are well recognized, the regulatory mechanisms controlling their expression remain understudied. This review explores the current understanding of these regulators, aiming to inspire strategies to combat bacterial resistance and improve therapeutic outcomes.
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