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Updated: Jul 23, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Hemolysis after pulsed-field ablation of atrial fibrillation
Yuankai Xu1, Taalaibek Kyzy Gulburak1, Yanmei Lu2
1Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Abstract:
Pulsed-field ablation (PFA) offers notable advantages in atrial fibrillation (AF) ablation by selectively targeting cardiomyocytes via an irreversible electroporation mechanism, thereby minimizing damage to surrounding tissues. Although clinical studies demonstrate that PFA is both safe and effective, PFA-mediated hemolysis and potential acute kidney injury (AKI) have been recently reported. This study comprehensively reviews the literature on PFA-associated hemolysis, analyzing the underlying mechanisms, risk factors, and preventive management strategies. In addition, the review discusses approaches to minimize the risk of PFA-induced hemolysis and AKI while offering insights for improving PFA-associated techniques.
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