Sensitive months for green spaces' impact on macrosomia and interaction with air pollutants: A birth cohort study

Macrosomia poses significant health risks to mother and fetuses, yet the protective sensitive window for the effects of green space resources on the risk of macrosomia remains unexplored. This study identified sensitive windows of green space exposure and examined the interactions with air pollutants. In a study of 221,380 full-term newborns delivered at the Hospital, from 2017 to 2021, Normalized Difference Vegetation Index (NDVI) and atmospheric pollutant concentrations were matched to participants based on their residences in the Ningxia region. A Cox proportional hazards model was utilized to estimate the association between green space exposure and macrosomia and analyze the differences between the macrosomia (<4500 g) and macrosomia (≥4500 g) groups. Green space exposure for each month of pregnancy was employed to identify possible sensitive windows. Possible interactions between green spaces and air pollutants were tested on additive and multiplicative scales. Across 250, 500, 1000, and 2000-m buffers, increased NDVI exposure and range throughout the pregnancy were linked to a lower macrosomia risk, with the strongest association in the macrosomia (≥4500 g) group. The key window for the protective effect of green spaces was in late pregnancy, with the most pronounced protective effect noted in the 9th month of pregnancy. We also found a consistent combined effect between low green space and the air pollutants (NO₂ and SO₂). The research highlights the beneficial impact of increased green space during late pregnancy and the combined effect of low green space and elevated air pollutant levels on macrosomia risk, which can support government initiatives in urban green space development and public health protection.