Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

182
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
182
Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

1.3K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
1.3K
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

1.6K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses...
1.6K
Thermoregulation01:26

Thermoregulation

881
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
881
Primary Motives: Hunger and Thirst01:25

Primary Motives: Hunger and Thirst

149
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
149
Body Temperature01:25

Body Temperature

894
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
894

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-Driven Grouping Model and Home Health Use Among Traditional Medicare Beneficiaries.

Journal of the American Medical Directors Association·2026
Same author

G Protein-Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models.

Obesity (Silver Spring, Md.)·2026
Same author

Improving incretin-mediated body weight loss via energy expenditure.

Trends in endocrinology and metabolism: TEM·2026
Same author

GCGR agonism requires GABAergic signaling in the medial basal hypothalamus to promote weight loss in obese mice.

Molecular metabolism·2026
Same author

High fat diet remodels the gene regulatory networks in the preoptic area.

Scientific reports·2026
Same author

IUPHAR review: From foe to friend: Repurposing glucagon to treat obesity and type 2 diabetes.

Pharmacological research·2026

Related Experiment Video

Updated: May 30, 2025

Author Spotlight: Hypothalamic Neural Mechanism Insights
09:29

Author Spotlight: Hypothalamic Neural Mechanism Insights

Published on: August 4, 2023

3.4K

Hypothalamic neural circuits regulating energy expenditure.

Rashmita Basu1, Jonathan N Flak1

  • 1Lilly Diabetes Research Center, Indiana Biosciences Research Institute, Indianapolis, IN, United States; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States.

Vitamins and Hormones
|January 26, 2025
PubMed
Summary

The hypothalamus regulates energy balance and homeostasis, adapting to nutrient availability. Understanding its function is key to addressing metabolic disorders like obesity.

Keywords:
BrainBrown adipose tissueCNSEnergy balanceHypothalamic dysfunctionObesityThermogenesisThermoregulation

More Related Videos

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
06:57

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

5.1K
Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
11:45

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

12.1K

Related Experiment Videos

Last Updated: May 30, 2025

Author Spotlight: Hypothalamic Neural Mechanism Insights
09:29

Author Spotlight: Hypothalamic Neural Mechanism Insights

Published on: August 4, 2023

3.4K
Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
06:57

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

5.1K
Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
11:45

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

12.1K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Metabolism

Background:

  • The hypothalamus is vital for energy homeostasis and survival.
  • It adapts to environmental changes and integrates physiological cues.
  • Hypothalamic nuclei process nutrient and hormonal signals.

Purpose of the Study:

  • To elucidate the hypothalamus's role in energy expenditure.
  • To understand its adaptive mechanisms in different nutritional contexts.
  • To explore its potential as a therapeutic target for metabolic disorders.

Main Methods:

  • Review of hypothalamic nuclei and neuron populations.
  • Analysis of communication between hypothalamus and peripheral organs.
  • Examination of evolutionary adaptations in energy storage.

Main Results:

  • The hypothalamus integrates sensory, physiological, and humoral factors.
  • It communicates with organs like the GI tract, liver, and adipose tissue.
  • It evolved for energy storage but contributes to obesity in caloric abundance.

Conclusions:

  • Hypothalamic function is crucial for whole-body energy homeostasis.
  • Understanding its neural control offers insights into metabolic states.
  • Targeting hypothalamic pathways may lead to new metabolic disorder treatments.