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Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
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Pathogenesis-Associated Bacterial Amyloids: The Network of Interactions
Haidar Fayoud1,2, Mikhail V Belousov1,2, Kirill S Antonets1,2
1Faculty of Biology, St. Petersburg State University, St. Petersburg, 199034, Russia.
Biochemistry. Biokhimiia
|January 26, 2025
Summary
Bacterial amyloids contribute to disease pathogenesis and biofilm formation. These microbial amyloids, alongside host and dietary amyloids, form a complex network influencing human health and disease.
Area of Science:
- Microbiology
- Biochemistry
- Immunology
Background:
- Amyloids are protein aggregates with a cross-β structure, known for resistance and involvement in pathogenesis and function.
- Bacteria exhibit diverse functional amyloids, primarily linked to virulence, biofilm formation, and host colonization.
- Emerging research highlights amyloids' role in spatial proteome regulation and their presence within the human holobiont.
Purpose of the Study:
- To review bacterial amyloids involved in human disease pathogenesis.
- To discuss the significance of bacterial amyloids within the holobiont-associated amyloid network.
- To explore the complex interactions between bacterial, host, and external amyloids.
Main Methods:
- Literature review of studies on bacterial amyloids and their roles in disease.
- Analysis of the functional and pathological implications of bacterial amyloids.
- Discussion of the interplay within the three-component holobiont amyloid network.
Main Results:
- Bacterial amyloids are crucial for virulence, aiding in biofilm formation and host adaptation.
- Amyloids can modulate the aggregation of other proteins, influencing proteome organization.
- The human holobiont comprises amyloids from host, microbiome, and external sources, creating a complex network.
Conclusions:
- Bacterial amyloids play a significant role in human disease pathogenesis.
- The interaction of bacterial, host, and dietary amyloids adds complexity to understanding amyloid-related diseases.
- Further research into microbiome-produced amyloids is essential for understanding holobiont health.
Keywords:
amyloidamyloid networkbacteriabeta-sheetcross-seedingfibrilholobionthumaninfectionpathogenesisprotein aggregatevirulenceMore Related Videos
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