Related Experiment Video
Updated: Aug 18, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Antagonism of brain opioid peptide action reduces hibernation bout duration
Abstract:
The effect of continuous intracerebroventricular (i.c.v.) administration of naloxone on the duration of individual bouts of hibernation was investigated in the golden-mantled ground squirrel (Citellus lateralis). Following entrance into hibernation, naloxone was continuously administered by an osmotic minipump at a rate of 1 microliter/h through a chronically implanted unilateral i.c.v. cannula guide. Naloxone (1, 5 and 7.5 micrograms/microliter) produced a dose-dependent reduction in hibernation bout duration ranging from 1 to 4 days (13.9-62.3% of expected bout duration). These data suggest that selected endogenous opioid system neurons may contribute to the CNS maintenance of the hibernating state and, consequently, to the overall conservation of energy in this species.
Related Concept Videos
Drug-Receptor Interaction: Antagonist
Antagonists can be classified as competitive or noncompetitive based on their...
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
Desensitization and Tachyphylaxis
Several...
Opioid Receptors: Overview
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids

