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Updated: May 30, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
A complex interplay between histone variants and DNA methylation
Alejandro Edera1, Leandro Quadrana1
1Institute of Plant Sciences Paris-Saclay (IPS2), Centre National de la Recherche Scientifique, Institut National de la Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université Evry, Université Paris-Saclay, 91405 Orsay, France.
None:
Nucleosomes, the chromatin building blocks, play an important role in controlling DNA and chromatin accessibility. Nucleosome remodeling and the incorporation of distinct histone variants confer unique structural and biochemical properties, influencing the targeting of multiple epigenetic pathways, particularly DNA methylation. This stable epigenetic mark suppresses transposable element expression in plants and mammals, serving as an additional layer of chromatin regulation. In this review, we explore recent advances in our understanding of the complex interplay between histone variants and DNA methylation in plants, and discuss the role that chromatin remodeling plays in coordinating histone exchange and methylation of DNA.
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