Age-related differences in thermoregulatory responses to endotoxin in rabbits

E. coli endotoxin evokes fever in rabbits immediately after birth. In 0--3 day-old rabbits the fever is monophasic and brown fat thermogenesis is mainly responsible for the reaction. In 6--10 day-old animals the fever is usually biphasic and increased heat conservation also contributes to the response. An inverse relationship exists between the endotoxin dose and the latent period before the onset of fever, while the height of the fever is independent of the endotoxin dose. The response is similar as that of adult rabbits, except that after all endotoxin doses the latent period is longer and the magnitude of the response slightly smaller in the newborn.