Related Experiment Video

Updated: May 30, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

500

Association between neutrophil-to-lymphocyte ratio and left ventricular diastolic dysfunction in patients with type 2

Xueyang Yang1,2, Yinze Shi1,2, Huan Zhang1,2

  • 1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Endocrinology
|January 27, 2025
PubMed

Insights

The neutrophil-to-lymphocyte ratio (NLR) may help identify left ventricular diastolic dysfunction (LVDD) in type 2 diabetes patients. Higher NLR levels correlate with increased LVDD prevalence, suggesting it as a potential diagnostic indicator.

Area of Science:

  • Cardiology
  • Endocrinology
  • Inflammation Biomarkers

Background:

  • Diabetes mellitus is a global pandemic linked to severe health complications.
  • Left ventricular diastolic dysfunction (LVDD) is a common, often asymptomatic, cardiac complication in diabetic patients.
  • The neutrophil-to-lymphocyte ratio (NLR) is an inflammation biomarker with potential links to cardiac conditions, but its association with LVDD in type 2 diabetes mellitus (T2DM) remains unexplored.

Purpose of the Study:

  • To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and left ventricular diastolic dysfunction (LVDD) in patients with type 2 diabetes mellitus (T2DM).

Main Methods:

  • A cross-sectional study analyzed medical records of 855 T2DM patients.
  • Patients were classified into LVDD and non-LVDD groups based on echocardiographic criteria.
  • The correlation between NLR levels and LVDD prevalence was statistically evaluated.

Main Results:

  • The prevalence of LVDD was 47.8% among the studied T2DM patients.
  • Patients with LVDD exhibited significantly higher mean NLR values compared to those without LVDD (P<0.001).
  • Logistic analysis revealed a positive association between NLR levels and LVDD prevalence, with elevated NLR correlating to increased odds of LVDD (P<0.001).

Conclusions:

  • The neutrophil-to-lymphocyte ratio (NLR) shows potential as an indicator for identifying LVDD in T2DM patients.
  • Elevated NLR levels may signify a higher risk of LVDD, warranting clinical attention and intervention to prevent progression to heart failure.
Abstract

Keywords:
heart failureinflammatory biomarkersleft ventricular diastolic dysfunctionneutrophil-to-lymphocyte ratiotype 2 diabetes mellitus

More Related Videos

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

10.1K
Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.1K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
500