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Updated: May 5, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Varied Clinical Features and Outcomes of Autoimmune Encephalitis: A Retrospective Case Series
Aruna Kumari Kotteti1, Elanthiraiyan Govindaswamy Chelvakumar1, Robert Wilson Sundaram1
1Neurology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND.
Introduction:
This study discusses the various clinical profiles, investigatory findings, treatment responses, and prognosticating factors in seven cases of autoimmune encephalitis (AE).
Methods:
The clinical records of seven AE patients admitted to the Neurology Department, SRM Medical College Hospital and Research Centre, Chennai, from July 2022 to December 2023 were retrospectively analyzed.
Results:
The patients' ages ranged from 18 to 35, and all experienced seizures. Only two patients exhibited cognitive decline and psychiatric problems. All seven cases were clinically diagnosed as AE: three were positive for anti-N-methyl-D-aspartate receptor (anti-NMDAR) antibodies, while the AE panel was negative in the remaining patients. In all cases, contrast imaging of the brain on MRI appeared normal.
Conclusion:
Patients with AE need to be diagnosed early because prompt immunosuppressive therapy effectively reduces morbidity and mortality. A detailed history, clinical examinations, and relevant investigations are required. Mild and atypical forms with negative autoimmune antibody panels with relatively good outcomes are increasingly encountered.
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