Related Experiment Video

Updated: Jul 8, 2026

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.3K

Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk

Xin-Yi Feng1, Yu-Cong Zheng2, Ying-Xia Yang3

  • 1Department of Radiology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, China.

Reviews in Cardiovascular Medicine
|January 27, 2025
PubMed

Insights

Dilated cardiomyopathy involves impaired heart function, potentially leading to heart failure. Cardiac MRI techniques like T1 mapping can assess myocardial fibrosis, aiding in risk stratification for patients with this condition.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Pathology

Background:

  • Dilated cardiomyopathy (DCM) is a severe heart condition characterized by impaired ventricular function.
  • DCM can lead to heart failure, ventricular arrhythmia, and sudden cardiac death, often necessitating heart transplantation.
  • Myocardial fibrosis, a key pathological feature, significantly contributes to adverse events in DCM.

Purpose of the Study:

  • To comprehensively assess myocardial fibrosis in DCM.
  • To evaluate the role of cardiac magnetic resonance imaging (CMR) in prognostic evaluation and risk stratification of DCM patients.
  • To compare different CMR techniques for fibrosis detection.

Main Methods:

  • Review of current literature on DCM and myocardial fibrosis.
  • Analysis of cardiovascular magnetic resonance (CMR) techniques, including Late Gadolinium Enhancement (LGE), T1 mapping, and extracellular volume (ECV) fraction mapping.
  • Comparison of CMR findings with pathological assessments of myocardial fibrosis.

Main Results:

  • Late Gadolinium Enhancement (LGE) is the gold standard for replacement fibrosis but has limitations in detecting diffuse interstitial fibrosis.
  • T1 mapping and ECV mapping show promise as complementary or alternative methods for interstitial fibrosis assessment.
  • CMR imaging provides valuable prognostic information and aids in risk stratification for DCM patients.

Conclusions:

  • Myocardial fibrosis is a critical determinant of outcomes in DCM.
  • Advanced CMR techniques, beyond LGE, are essential for comprehensive fibrosis evaluation.
  • CMR-based fibrosis assessment is crucial for guiding clinical management and risk stratification in DCM.

Keywords:
T1 mapping imagingcardiac magnetic resonancedilated cardiomyopathylate gadolinium enhancementmyocardial fibrosisprognosis

More Related Videos

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

9.9K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

9.9K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...