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Related Experiment Video

Updated: May 30, 2025

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Coronary Microvascular Dysfunction: Insights on Prognosis and Future Perspectives.

Filippo Luca Gurgoglione¹, Giorgio Benatti², Andrea Denegri²

¹Division of Cardiology, University of Parma, Parma University Hospital, 14 - 43126 Parma, Italy.

Reviews in Cardiovascular Medicine

|January 27, 2025

Summary

Coronary microvascular dysfunction (CMD) causes heart problems and impacts quality of life. This review covers CMD

Keywords:

coronary microvascular dysfunction heart failure with preserved ejection fraction major adverse cardiovascular events quality of life

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Area of Science:

Cardiology
Vascular Biology

Background:

Coronary microvascular dysfunction (CMD) involves abnormalities in small heart vessels, leading to ischemia.
CMD is increasingly recognized as a significant contributor to cardiovascular morbidity and mortality.
It is linked to major adverse cardiovascular events (MACEs) and heart failure with preserved ejection fraction.

Purpose of the Study:

To review the pathogenesis and diagnostic methods for CMD.
To summarize current evidence on the prognostic implications of CMD.
To provide an overview of emerging therapeutic strategies for CMD.

Main Methods:

Literature review of existing studies on coronary microvascular dysfunction.
Synthesis of information on CMD pathogenesis, diagnosis, prognosis, and treatment.
Focus on contemporary evidence and novel therapeutic approaches.

Main Results:

CMD encompasses structural and functional issues of the coronary microcirculation.
CMD is associated with adverse cardiovascular outcomes, including MACEs and heart failure.
Prognostic impact of CMD is significant, affecting patient quality of life.

Conclusions:

Understanding CMD pathogenesis and diagnosis is crucial for patient management.
CMD carries a substantial prognostic burden.
Novel therapeutic strategies are under investigation to improve outcomes for patients with CMD.