Related Experiment Video

Updated: Jun 9, 2026

Transcutaneous Assessment of Renal Function in Conscious Rodents
07:18

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

12.4K

Evaluating SCUBE-1 as Predictive Biomarker for Hypertension-Mediated Organ Damage: A Comparative Study

Betül Ayça Yamak1, Mustafa Candemir1, Emrullah Kızıltunç1

  • 1Department of Cardiology, Gazi University Faculty of Medicine, 06560 Ankara, Turkey.

Reviews in Cardiovascular Medicine
|January 27, 2025
PubMed

Insights

Serum signal peptide, CUB domain, and EGF-like domain-containing protein 1 (SCUBE-1) is elevated in hypertension patients with organ damage. Higher SCUBE-1 levels indicate greater hypertension-mediated organ damage (HMOD), suggesting its potential as a biomarker.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Hypertension Studies

Background:

  • Hypertension-mediated organ damage (HMOD) is a major complication affecting cardiac, retinal, and renal systems.
  • Serum signal peptide, CUB domain, and EGF-like domain-containing protein 1 (SCUBE-1) is a novel biomarker associated with vascular pathology.
  • Investigating SCUBE-1's role in detecting HMOD is crucial for patient outcomes.

Purpose of the Study:

  • To explore the relationship between SCUBE-1 levels and HMOD in hypertensive individuals.
  • To assess the diagnostic utility of SCUBE-1 for detecting HMOD in hypertension.

Main Methods:

  • A cross-sectional study involving 115 participants (79 hypertensive, 36 controls).
  • Hypertensive patients were categorized based on the presence or absence of HMOD.
  • SCUBE-1 levels were quantified and analyzed for diagnostic accuracy.

Main Results:

  • Hypertensive patients showed significantly higher SCUBE-1 levels (160.70 ng/mL) than controls (75.64 ng/mL).
  • Patients with HMOD exhibited markedly elevated SCUBE-1 levels (311.27 ng/mL) compared to those without HMOD (142.53 ng/mL).
  • SCUBE-1 demonstrated significant diagnostic potential for cardiac (AUC 0.722), retinal (AUC 0.761), and renal (AUC 0.707) damage.

Conclusions:

  • SCUBE-1 levels are significantly elevated in hypertensive patients, especially those with HMOD.
  • SCUBE-1 shows promise as a valuable biomarker for predicting organ damage in hypertension.
  • Further research can validate SCUBE-1 for clinical application in HMOD assessment.
Abstract

Keywords:
SCUBE-1biomarkerendothelial dysfunctionhypertensionhypertension-mediated organ damage

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.3K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:37

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

91

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...