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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

Updated: May 30, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
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Functionally enriched human polymorphisms associate to species in the chronic wound microbiome.

Rebecca A Gabrilska, Khalid Omeir, Jacob Ancira

    Medrxiv : the Preprint Server for Health Sciences
    |January 27, 2025
    PubMed
    Summary

    Human genetics influences chronic wound bacteria composition. A microbiome genome-wide association study (mbGWAS) identified genetic loci linked to bacterial species, impacting wound healing and pathogen interactions.

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    Area of Science:

    • Microbiology
    • Genetics
    • Wound Healing Research

    Background:

    • Chronic wounds affect millions globally, necessitating novel treatments.
    • Impaired wound healing is linked to wound microbiota composition.
    • Human genetics may influence individual wound microbiome differences.

    Purpose of the Study:

    • To investigate the impact of human genetics on chronic wound microbiome composition.
    • To identify genetic loci associated with specific bacterial species in wounds.
    • To explore the interplay between host genetics, wound microbiota, and healing.

    Main Methods:

    • A two-stage microbiome genome-wide association study (mbGWAS) was conducted.
    • Bacterial 16S rRNA gene sequencing was used to analyze wound microbiota.
    • Statistical analyses identified associations between genetic loci and bacterial species abundances.

    Main Results:

    • Sixteen bacterial species showed significant associations with 193 genetic loci.
    • Heritability estimates for species abundance ranged up to 20%.
    • Genetics influenced pathways related to microbial infection and wound healing, and co-occurrence with pathogens like *Staphylococcus aureus*.

    Conclusions:

    • Host genetics significantly shape the chronic wound microbiome.
    • Genetic biomarkers can provide mechanistic insights into patient-microbiome interactions.
    • This research offers potential for identifying predictive risk factors for chronic wound management.