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Updated: May 30, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

An evolutionary perspective for the exposome.

Paolo Vineis¹, Sonia Dagnino^1,2

¹MRC Centre for Environment and Health, School of Public Health, Imperial College, London, UK.

|January 27, 2025

Summary

This summary is machine-generated.

The exposome concept, focusing on environmental exposures and disease, is expanded to include evolutionary principles like phenotypic plasticity. This broader view is crucial for understanding complex diseases such as cancer in a changing world.

Keywords:

agnostic research environment evolutionary theory human health phenotypic plasticity theory-driven research

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Area of Science:

Environmental Health
Evolutionary Biology
Disease Etiology

Background:

Most human diseases stem from environmental factors, not genetics.
Non-communicable diseases arise from cumulative, lifelong exposures starting early in life.
The exposome concept addresses the totality of exposures from conception onwards.

Purpose of the Study:

To extend the exposome concept using a Darwinian approach and phenotypic plasticity.
To advocate for a broader interpretation of exposome science beyond "precision environmental research."
To integrate evolutionary biology and medicine for a comprehensive understanding of disease causation.

Main Methods:

Conceptual analysis extending the exposome framework.
Incorporation of evolutionary principles, including phenotypic plasticity.
Examination of "Darwinian carcinogenesis" as a model.

Main Results:

A broadened exposome concept integrating evolutionary adaptation is proposed.
Current exposome research is a partial view, often limited to chemical exposures.
A wider perspective is necessary, especially considering the planetary crisis.

Conclusions:

The exposome concept requires an evolutionary lens to fully grasp disease development.
Understanding adaptation to environmental change is key to addressing complex diseases.
Integrating evolutionary medicine offers a more complete approach to environmental health research.