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Exploring the Epidemiological Characteristics and Survival Analysis Among Prostate Cancer Patients Under 50: A
Bahaa Mali1, Ali Mali1, Alaa Mali1
1Faculty of Medicine Al Quds University Jerusalem Palestine.
Health Science Reports
|January 27, 2025
Summary
Prostate cancer incidence is rising in men under 50. Early-onset prostate cancer shows lower survival rates, with diagnosis under 30, advanced stage, and non-Hispanic black race negatively impacting prognosis.
Area of Science:
- Oncology
- Epidemiology
- Urology
Background:
- Aging is a known risk factor for prostate cancer.
- Prostate cancer incidence and mortality are increasing in younger men.
- Limited knowledge exists on recent trends in early-onset prostate cancer.
Purpose of the Study:
- To analyze prostate cancer incidence trends in men under 50 from 1975 to 2020.
- To examine survival rates and risk factors in this demographic.
- To provide insights for improved management strategies.
Main Methods:
- Utilized Surveillance, Epidemiology, and End Results (SEER) registries data (SEER 8 and SEER 22).
- Analyzed incidence, frequency, and survival rates by age, stage, and race.
- Employed multivariable Cox proportional hazards regression models to identify risk factors.
Main Results:
- Prostate cancer incidence in men under 50 has increased from 1975 to 2020.
- Between 2004-2020, 35,670 cases were diagnosed, with 76.10% localized.
- Diagnosis under 30, advanced stage, and non-Hispanic black race were associated with poorer prognosis.
Conclusions:
- Early-onset prostate cancer exhibits unique epidemiological and clinical features.
- Further research into biological, genetic, and environmental factors is crucial.
- Enhanced understanding will aid in developing targeted management plans to improve survival rates.
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